RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice

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	RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice
	Liu, Naixin; Wang, Ying; Zeng, Lin; Yin, Saige; Hu, Yan; Li, Shanshan; Fu, Yang; Zhang, Xinping; Xie, Chun; Shu, Longjun; Li, Yilin; Sun, Huiling; Yang, Meifeng; Sun, Jun; Yang, Xinwang
	2020
发表期刊	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN	0021-8561
卷号	68 期号:27 页码:7143-7151
摘要	Gout and hyperuricemia can seriously affect the quality of life; at present, however, existing medicines are unable to meet all clinical needs. In the current study, a novel peptide (i.e., rice-derived-peptide-3 (RDP3), AAAAMAGPK-NH2, 785.97 Da) in water extract obtained from shelled Oryza sativa fruits was identified. Testing revealed that RDP3 (minimum effective concentration 100 mu g/kg) did not show both hemolytic and acute toxicity, and reduced uric acid levels in the serum of hyperuricemic mice by inhibiting xanthine oxidase activity and decreasing urate transporter 1 expression. RDP3 also alleviated renal injury in hyperuricemic mice by decreasing NLRP3 inflammasome expression. Furthermore, RDP3 alleviated formalin-induced paw pain and reduced monosodium urate crystal-induced paw swelling and inflammatory factors in mice. Thus, this newly identified peptide reduced uric acid levels and renal damage in hyperuricemic mice and showed anti-inflammatory and analgesic activities, indicating the potential of RDP3 as an antigout medicine candidate.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12927
专题	管理、支撑部门_大型仪器中心
推荐引用方式 GB/T 7714	Liu, Naixin,Wang, Ying,Zeng, Lin,et al. RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(27):7143-7151.
APA	Liu, Naixin.,Wang, Ying.,Zeng, Lin.,Yin, Saige.,Hu, Yan.,...&Yang, Xinwang.(2020).RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(27),7143-7151.
MLA	Liu, Naixin,et al."RDP3, A Novel Antigout Peptide Derived from Water Extract of Rice".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.27(2020):7143-7151.

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