RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling

KIZ OpenIR > 科研部门 > 发育生物学（毛炳宇）

	RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling
	Ma, Pengcheng; An, Tao; Zhu, Liang; Zhang, Longlong; Wang, Huishan; Ren, Biyu; Sun, Bin; Zhou, Xia; Li, Yan; Mao, Bingyu
	2020
发表期刊	DEVELOPMENT
ISSN	0950-1991
卷号	147 期号:21
摘要	Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule neuron progenitors (CGNPs) and its misregulation is linked to various disorders, including the cerebellar cancer medulloblastoma (MB). We recently identified RNF220, a ubiquitin E3 ligase promoting K63-linked polyubiquitylation and nuclear exportation of Gli transcription factors, as an Shh/Gli regulator involved in ventral neural patterning. Here, we report that RNF220 is required for the proliferation of CGNPs and Daoy cells (an Shh-grouped MB cell line), working as a positive regulator of Shh signaling. Mechanistic investigation demonstrated that RNF220 promotes Shh target gene expression by targeting the PRC2 component EED, and alters levels of epigenetic modification marks on Shh target promoters. We provided evidence that RNF220(+/-); Ptch1(+/-) mice showed lower spontaneous MB occurrence compared with Ptch1(+/-) mice. Furthermore, in human clinical MB samples, RNF220 expression correlated well with that of GAB1, an Shh-group MB marker. Our findings provide new insights into the epigenetic regulation of Shh signaling and identify RNF220 as a potential new diagnostic marker and therapeutic target for Shh-group MB.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12929
专题	科研部门_发育生物学（毛炳宇）
推荐引用方式 GB/T 7714	Ma, Pengcheng,An, Tao,Zhu, Liang,et al. RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling[J]. DEVELOPMENT,2020,147(21).
APA	Ma, Pengcheng.,An, Tao.,Zhu, Liang.,Zhang, Longlong.,Wang, Huishan.,...&Mao, Bingyu.(2020).RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling.DEVELOPMENT,147(21).
MLA	Ma, Pengcheng,et al."RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling".DEVELOPMENT 147.21(2020).

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