Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNAFENDRRin Lung Cancer in Xuanwei, China

	Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNAFENDRRin Lung Cancer in Xuanwei, China
	Duan, Yong; Li, Wen-Xing; Wang, Yan; Zhao, Ying; Shen, Jie; Deng, Cheng-Jun; Li, Qing; Chen, Ran; Liu, Xiao; Zhang, Yan-Liang
	2021
发表期刊	NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
ISSN	0163-5581
卷号	73 期号:6 页码:983-995
摘要	This study was to screen out potential driver long non-coding RNAs (lncRNAs) in lung cancer in Xuanwei (LCXW) differently expressed mRNAs and lncRNAs were detected by gene expression microarrays in 23 paired lung adenocarcinoma and adjacent tissues. Combined bioinformatics analysis was performed to identify potential driver lncRNAs and their potential regulatory relationships. Transcriptome and clinical data in TCGA-LUAD were used as comparison and validation dataset. The comparison of LCXW and TCGA-LUAD revealed significant differences in expression of some genes, signaling pathways affected by differentially expressed genes, and the 5-year survival rate of patients. We identified 14 consistently deregulated mRNAs and 5 lncRNAs as candidate genes, which affected multiple cancer-related pathways and influenced patients' overall survival. By combined bioinformatics analysis, we further identified a potential driver lncRNAfetal-lethal non-coding developmental regulatory RNA(FENDRR) and proposed its possible regulation mechanism. The low expression ofFENDRRwas positively correlated withKruppel-like factor4(KLF4),KLF4down-regulation may loss the activation function ofcyclin-dependent kinase inhibitor 1A(CDKN1A) andcyclin-dependent kinase inhibitor 1C(CDKN1C) and the inhibition function ofCyclinB1(CCNB1), eventually cause excessive cell cycle activation and lead to lung cancer. This study revealed a potentialFENDRR-KLF4-cell cycle regulation axis. These results lay an important foundation for further research on the pathogenesis of LCXW and identification of potential novel biomarkers or therapeutic targets.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12945
专题	科研部门_动物模型与人类重大疾病机理重点实验室
推荐引用方式 GB/T 7714	Duan, Yong,Li, Wen-Xing,Wang, Yan,et al. Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNAFENDRRin Lung Cancer in Xuanwei, China[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2021,73(6):983-995.
APA	Duan, Yong.,Li, Wen-Xing.,Wang, Yan.,Zhao, Ying.,Shen, Jie.,...&Zhang, Yan-Liang.(2021).Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNAFENDRRin Lung Cancer in Xuanwei, China.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,73(6),983-995.
MLA	Duan, Yong,et al."Integrated Analysis of lncRNAs and mRNAs Identifies a Potential Driver lncRNAFENDRRin Lung Cancer in Xuanwei, China".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 73.6(2021):983-995.

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