HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer

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	HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer
	Fang, H; Du, GS; Wu, QJ; Liu, R; Chen, CS; Feng, J
	2019
发表期刊	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN	1672-9145
卷号	51 期号:10 页码:1064-1070
摘要	Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor clinical outcomes and without effective targeted therapies. Numerous studies have suggested that HDAC inhibitors (TSA/SAHA) may be effective in TNBCs. Proline oxidase, also known as proline dehydrogenase (POX/PRODH), is a key enzyme in the proline metabolism pathway and plays a vital role in tumorigenesis. In this study, we found that HDAC inhibitors (TSA/SAHA) significantly increased POX expression and autophagy through activating AMPK. Depletion of POX decreased autophagy and increased apoptosis induced by HDAC inhibitors in TNBC cells. These results suggest that POX contributes to cell survival under chemotherapeutic stresses and might serve as a potential target for treatment of TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12974
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Fang, H,Du, GS,Wu, QJ,et al. HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2019,51(10):1064-1070.
APA	Fang, H,Du, GS,Wu, QJ,Liu, R,Chen, CS,&Feng, J.(2019).HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,51(10),1064-1070.
MLA	Fang, H,et al."HDAC inhibitors induce proline dehydrogenase (POX) transcription and anti-apoptotic autophagy in triple negative breast cancer".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 51.10(2019):1064-1070.

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