Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2
	Zhou, WH; Fang, H; Wu, QJ; Wang, XY; Liu, R; Li, FB; Xiao, J; Yuan, L; Zhou, ZM; Ma, JY; Wang, LL; Zhao, WW; You, H; Ju, JH; Feng, J; Chen, CS
	2019
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	15 期号:8 页码:1723-1732
摘要	Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women in the worldwide. Triple-negative breast cancer (TNBC) has a poor clinical outcome. The antitumor efficacy of Ilamycins, natural products with anti-tuberculosis activity isolated from deep sea-derived Streptomyces atratus, in TNBC has not been investigated, and the mechanisms remain elusive. Here, we demonstrated that Ilamycin-E, but not -F, decreases cell viability, inhibits G1/S cell cycle progression, and promotes apoptosis in the TNBC cell lines HCC1937 and MDA-MB-468. Ilamycin E promotes apoptosis via activation of endoplasmic reticulum (ER) stress, increasing the expression of CHOP, and down-regulating the expression of anti-apoptotic protein Bcl-2. Depletion of CHOP or overexpression of Bcl2 significantly rescued Ilamycin E-induced apoptosis. These findings indicate that Ilamycin E has anti-cancer activity in TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12975
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Zhou, WH,Fang, H,Wu, QJ,et al. Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(8):1723-1732.
APA	Zhou, WH.,Fang, H.,Wu, QJ.,Wang, XY.,Liu, R.,...&Chen, CS.(2019).Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(8),1723-1732.
MLA	Zhou, WH,et al."Ilamycin E, a natural product of marine actinomycete, inhibits triple-negative breast cancer partially through ER stress-CHOP-Bcl-2".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.8(2019):1723-1732.

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