Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers

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	Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers
	Chen, CH; Yang, N; Zhang, YC; Ding, JC; Zhang, WJ; Liu, R; Liu, W; Chen, CS
	2019
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1449-2288
卷号	15 期号:8 页码:1733-1742
摘要	The transcription factor KLF5 (Krupple-like factor 5) is highly expressed in basal-like breast cancer (BLBC), which promotes cell proliferation, survival, migration and stemness, serving as a potential therapeutic target. In the current study, a super-enhancer (SE) was identified to be located downstream of the KLF5 gene in BLBC cell lines, HCC1806 and HCC1937. JQ-1, a BRD4 inhibitor, inhibits the expression and activity of KLF5 in both HCC1806 and HCC1937 cells in a time-and dose-dependent manner. Compound 870, an in-house BRD4 inhibitor, exhibited higher potency than JQ-1 to inhibit KLF5 and BLBC growth by arresting cells in G1 phase. Additionally, THZ1, a CDK7 inhibitor, also inhibits KLF5 and BLBC growth in a similar manner. Our findings suggested that KLF5 is regulated by SE, and modulation of SE could be an effective therapeutic strategy for treating BLBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12976
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Chen, CH,Yang, N,Zhang, YC,et al. Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2019,15(8):1733-1742.
APA	Chen, CH.,Yang, N.,Zhang, YC.,Ding, JC.,Zhang, WJ.,...&Chen, CS.(2019).Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,15(8),1733-1742.
MLA	Chen, CH,et al."Inhibition of super enhancer downregulates the expression of KLF5 in basal-like breast cancers".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 15.8(2019):1733-1742.

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