Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas
	Li, LL; Fan, YC; Huang, X; Luo, J; Zhong, L; Shu, XS; Lu, L; Xiang, TX; Chan, ATC; Yeo, WN; Chen, CS; Chan, WY; Huganir, RL; Tao, Q
	2019
发表期刊	ISCIENCE
卷号	21 页码:1+
摘要	Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and different from other RASA family members (RASA1-RASA4), indicating its special functions in tumorigenesis. RASA5 mutations are rare, unlike other RASA members, whereas its promoter CpG methylation is frequent in multiple cancer cell lines and primary carcinomas and associated with patient's poor survival. RASA5 expression inhibited tumor cell migration/invasion and growth in mouse model, functioning as a tumor suppressor. RASA5 suppressed RAS signaling, depending on its Ras GTPase-activating protein catalytic activity, which could be counteracted by oncogenic HRas Q61L mutant. RASA5 knockdown enhanced Ras signaling to promote tumor cell growth. RASA5 also inhibited epithelial-mesenchymal transition (EMT) through regulating actin reorganization. Thus, epigenetic inactivation of RASA5 contributing to hyperactive RAS signaling is involved in Ras-driven human oncogenesis.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12978
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Li, LL,Fan, YC,Huang, X,et al. Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas[J]. ISCIENCE,2019,21:1+.
APA	Li, LL.,Fan, YC.,Huang, X.,Luo, J.,Zhong, L.,...&Tao, Q.(2019).Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas.ISCIENCE,21,1+.
MLA	Li, LL,et al."Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas".ISCIENCE 21(2019):1+.

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