Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression
	He, LL; Yuan, L; Sun, Y; Wang, PY; Zhang, HL; Feng, X; Wang, ZY; Zhang, WX; Yang, CY; Zeng, YA; Zhao, Y; Chen, CS; Zhang, L
	2019
发表期刊	CANCER RESEARCH
ISSN	0008-5472
卷号	79 期号:17 页码:4399-4411
摘要	The Hippo pathway plays a critical role in cell growth and tumorigenesis. The activity of TEA domain transcription factor 4 (TEAD4) determines the output of Hippo signaling; however, the regulation and function of TEAD4 has not been explored extensively. Here, we identified glucocorticoids (GC) as novel activators of TEAD4. GC treatment facilitated glucocorticoid receptor (GR)-dependent nuclear accumulation and transcriptional activation of TEAD4. TEAD4 positively correlated with GR expression in human breast cancer, and high expression of TEAD4 predicted poor survival of patients with breast cancer. Mechanistically, GC activation promoted GR interaction with TEAD4, forming a complex that was recruited to the TEAD4 promoter to boost its own expression. Functionally, the activation of TEAD4 by GC promoted breast cancer stem cells maintenance, cell survival, metastasis, and chemoresistance both in vitro and in vivo. Pharmacologic inhibition of TEAD4 inhibited GC-induced breast cancer chemoresistance. In conclusion, our study reveals a novel regulation and functional role of TEAD4 in breast cancer and proposes a potential new strategy for breast cancer therapy. Significance: This study provides new insight into the role of glucocorticoid signaling in breast cancer, with potential for clinical translation.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/12982
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	He, LL,Yuan, L,Sun, Y,et al. Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression[J]. CANCER RESEARCH,2019,79(17):4399-4411.
APA	He, LL.,Yuan, L.,Sun, Y.,Wang, PY.,Zhang, HL.,...&Zhang, L.(2019).Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression.CANCER RESEARCH,79(17),4399-4411.
MLA	He, LL,et al."Glucocorticoid Receptor Signaling Activates TEAD4 to Promote Breast Cancer Progression".CANCER RESEARCH 79.17(2019):4399-4411.

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2020110408.pdf（4258KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文