TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells

	TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells
	Zhao, LM; Li, LL; Xu, HB; Ke, H; Zou, L; Yang, Q; Shen, CKJ; Nie, JY; Jiao, BW
	2019
发表期刊	STEM CELLS AND DEVELOPMENT
ISSN	1547-3287
卷号	28 期号:14 页码:944-953
摘要	Mammary gland stem cells (MaSCs), assumed to be the original cells of breast cancer, play essential roles in regulating mammary gland homeostasis and development. Previously, we identified a crucial regulatory role of TAR DNA-binding protein 43 (TDP-43), an RNA-binding protein, in the progression of triple-negative breast cancer. However, the function of TDP-43 in MaSCs is unclear. Based on single-cell data analysis of the mammary gland, TDP-43 showed potential involvement in the regulation of MaSCs. We therefore investigated the effects of TDP-43 on the mammary gland development. Our data both in vitro and in vivo demonstrated that TDP-43 was required for the mammary gland repopulation, which suggested the potential role in the regulation of MaSCs. Knockdown of TDP-43 inhibited proliferation of mammary epithelial cells (MECs) and mammary morphogenesis. RNA-seq data and other experiments identified that loss of TDP-43 induced the upregulation of genes related to the cell cycle, providing a possible mechanism for TDP-43 in regulating mammary gland repopulation. Thus, our findings indicate a previously unknown role of TDP-43 in MECs.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13016
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Zhao, LM,Li, LL,Xu, HB,et al. TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells[J]. STEM CELLS AND DEVELOPMENT,2019,28(14):944-953.
APA	Zhao, LM.,Li, LL.,Xu, HB.,Ke, H.,Zou, L.,...&Jiao, BW.(2019).TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells.STEM CELLS AND DEVELOPMENT,28(14),944-953.
MLA	Zhao, LM,et al."TDP-43 is Required for Mammary Gland Repopulation and Proliferation of Mammary Epithelial Cells".STEM CELLS AND DEVELOPMENT 28.14(2019):944-953.

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