| 3 '-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels |
| Xu, RJ; Fei, SH; Chen, LY; Wang, G; Liu, M; Zhang, WS; Yan, XW; Lai, R; Shen, CB
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| 2019
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| 发表期刊 | CHINESE JOURNAL OF NATURAL MEDICINES
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| ISSN | 2095-6975
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| 卷号 | 17期号:6页码:413-423 |
| 摘要 | Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains unclear. Voltage-gated sodium channels (VGSCs) play important roles in excitability of pain sensing neurons and many of them are important nociceptors. Here, we report that several isoflavones including 3'-methoxydaidzein (3MOD), genistein (GEN) and daidzein (DAI) show abilities to block VGSCs and thus to attenuate chemicals and heat induced acute pain or chronic constriction injury (CCI) induced pain hypersensitivity in mice. Especially, 3MOD shows strong analgesic potential without inducing addiction through inhibiting subtypes Na(v)1.7, Na(v)1.8 and Na-v 1.3 with the IC50 of 181 +/- 14, 397 +/- 26, and 505 +/- 46 nmol.L-1, respectively, providing a promising compound or parent structure for the treatment of pain pathologies. This study reveals a pain-alleviating mechanism of dietary isoflavones and may provide a convenient avenue to alleviate pain. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13025
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Xu, RJ,Fei, SH,Chen, LY,et al. 3 '-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(6):413-423.
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| APA |
Xu, RJ.,Fei, SH.,Chen, LY.,Wang, G.,Liu, M.,...&Shen, CB.(2019).3 '-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels.CHINESE JOURNAL OF NATURAL MEDICINES,17(6),413-423.
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| MLA |
Xu, RJ,et al."3 '-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels".CHINESE JOURNAL OF NATURAL MEDICINES 17.6(2019):413-423.
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