| Antimicrobial peptides: new hope in the war against multidrug resistance |
| Mwangi, J; Hao, X; Lai, R; Zhang, ZY
|
| 2019
|
| 发表期刊 | ZOOLOGICAL RESEARCH
 |
| ISSN | 2095-8137
|
| 卷号 | 40期号:6页码:488-505 |
| 摘要 | The discovery of antibiotics marked a golden age in the revolution of human medicine. However, decades later, bacterial infections remain a global healthcare threat, and a return to the pre-antibiotic era seems inevitable if stringent measures are not adopted to curb the rapid emergence and spread of multidrug resistance and the indiscriminate use of antibiotics. In hospital settings, multidrug resistant (MDR) pathogens, including carbapenem-resistant Pseudomonas aeruginosa, vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and extended- spectrum beta-lactamases (ESBL) bearing Acinetobacter baumannii, Escherichia coli, and Kiebsiella pneumoniae are amongst the most problematic due to the paucity of treatment options, increased hospital stay, and exorbitant medical costs. Antimicrobial peptides (AMPs) provide an excellent potential strategy for combating these threats. Compared to empirical antibiotics, they show low tendency to select for resistance, rapid killing action, broad-spectrum activity, and extraordinary clinical efficacy against several MDR strains. Therefore, this review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs. |
| 收录类别 | SCI
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13028
|
| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
|
推荐引用方式
GB/T 7714 |
Mwangi, J,Hao, X,Lai, R,et al. Antimicrobial peptides: new hope in the war against multidrug resistance[J]. ZOOLOGICAL RESEARCH,2019,40(6):488-505.
|
| APA |
Mwangi, J,Hao, X,Lai, R,&Zhang, ZY.(2019).Antimicrobial peptides: new hope in the war against multidrug resistance.ZOOLOGICAL RESEARCH,40(6),488-505.
|
| MLA |
Mwangi, J,et al."Antimicrobial peptides: new hope in the war against multidrug resistance".ZOOLOGICAL RESEARCH 40.6(2019):488-505.
|
修改评论