SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE

	SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE
	Raihan, O; Brishti, A; Li, Q; Zhang, QL; Li, DF; Li, XH; Zhang, QY; Xie, ZW; Li, JL; Zhang, J; Liu, Q
	2019
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	28 期号:1 页码:78+
摘要	RNA binding proteins, the key regulators in gene expression at the posttranscriptional level, remain largely uncharacterized with respect to aging and relevant cognitive deterioration. Here, we report that the levels of SFRS11 are substantially decreased in the prefrontal cortex (PFC) of aged brains. Notably, mice with SFRS11 deficiency in the PFC show impaired learning and memory. We demonstrate that SFRS11 directly binds to the 3' UTR of LRP8 mRNA, as well as to the third exon of apoE mRNA, resulting in stabilization of these mRNAs, eventually deactivating JNK signaling. Importantly, restoration of LRP8 and apoE reduces JNK signaling that is significantly enhanced in SFRS11-deficient cells. In addition, LRP8 and apoE rescue aging-like phenotypes induced by SFRS11 loss. Our findings demonstrate that age-dependent loss of SFRS11 in the PFC reduces levels of apoE and LRP8, leading to activation of the JNK pathway, ultimately influencing cognitive deficits.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13036
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Raihan, O,Brishti, A,Li, Q,et al. SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE[J]. CELL REPORTS,2019,28(1):78+.
APA	Raihan, O.,Brishti, A.,Li, Q.,Zhang, QL.,Li, DF.,...&Liu, Q.(2019).SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.CELL REPORTS,28(1),78+.
MLA	Raihan, O,et al."SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE".CELL REPORTS 28.1(2019):78+.

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