The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host-Pathogen Arms Race in Birds

	The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host-Pathogen Arms Race in Birds
	Khan, I; Maldonado, E; Silva, L; Almeida, D; Johnson, WE; O'Brien, SJ; Zhang, GJ; Jarvis, ED; Gilbert, MTP; Antunes, A
	2019
发表期刊	DIVERSITY-BASEL
卷号	11 期号:8 页码:-
摘要	The vertebrate toll-like receptor (TLRs) supergene family is a first-line immune defense against viral and non-viral pathogens. Here, comparative evolutionary-genomics of 79 vertebrate species (8 mammals, 48 birds, 11 reptiles, 1 amphibian, and 11 fishes) revealed differential gain/loss of 26 TLRs, including 6 (TLR3, TLR7, TLR8, TLR14, TLR21, and TLR22) that originated early in vertebrate evolution before the diversification of Agnatha and Gnathostomata. Subsequent dynamic gene gain/loss led to lineage-specific diversification with TLR repertoires ranging from 8 subfamilies in birds to 20 in fishes. Lineage-specific loss of TLR8-9 and TLR13 in birds and gains of TLR6 and TLR10-12 in mammals and TLR19-20 and TLR23-27 in fishes. Among avian species, 5-10% of the sites were under positive selection (PS) (omega 1.5-2.5) with radical amino-acid changes likely affecting TLR structure/functionality. In non-viral TLR4 the 20 PS sites (posterior probability PP > 0.99) likely increased ability to cope with diversified ligands (e.g., lipopolysaccharide and lipoteichoic). For viral TLR7, 23 PS sites (PP > 0.99) possibly improved recognition of highly variable viral ssRNAs. Rapid evolution of the TLR supergene family reflects the host-pathogen arms race and the coevolution of ligands/receptors, which follows the premise that birds have been important vectors of zoonotic pathogens and reservoirs for viruses.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13057
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Khan, I,Maldonado, E,Silva, L,et al. The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host-Pathogen Arms Race in Birds[J]. DIVERSITY-BASEL,2019,11(8):-.
APA	Khan, I.,Maldonado, E.,Silva, L.,Almeida, D.,Johnson, WE.,...&Antunes, A.(2019).The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host-Pathogen Arms Race in Birds.DIVERSITY-BASEL,11(8),-.
MLA	Khan, I,et al."The Vertebrate TLR Supergene Family Evolved Dynamically by Gene Gain/Loss and Positive Selection Revealing a Host-Pathogen Arms Race in Birds".DIVERSITY-BASEL 11.8(2019):-.

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