| Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia |
| Lang, DT; Lim, BK; Gao, Y; Wang, XP
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| 2019
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| 发表期刊 | INTEGRATIVE ZOOLOGY
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| ISSN | 1749-4877
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| 卷号 | 14期号:3页码:306-317 |
| 摘要 | Ribonuclease 6 (RNase6 or RNase K6) is a protein that belongs to a superfamily thought to be the sole verte-brate-specific enzyme known for a wide range of physiological functions, including digestion, cytotoxicity, angiogenesis, male reproduction and host defense. In our study, 51 functional genes and 11 pseudogenes were identified from 27 Rodentia species. Intriguingly, in the 3 main lineages of rodents there were multiple RNase6s identified in all species of Ctenohystrica, whereas only a single RNase6 was observed in other Rodentia species examined except for 2 species in the mouse-related clade. The evolutionary scenario of birth (gene duplication) and death (gene deactivation) and gene sorting have been demonstrated in Ctenohystrica. In addition, bursts of positive selection, diversification of isoelectric point and positive net charge have been identified in Ctenohystrica, especially at two key sites that are involved in antimicrobial function. Site Trp30 has undergone positive selection and Ile45 has changed into other residues in Group B and Group C of the Ctenohystrica. Our results demonstrated a complex and intriguing evolutionary pattern of rodent RNase6, and indicated that functional modification may have occurred, which establishes an important theoretical foundation for future functional assays in rodent RNase6. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13058
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| 专题 | 科研部门_分子进化与基因组多样性（张亚平）
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推荐引用方式
GB/T 7714 |
Lang, DT,Lim, BK,Gao, Y,et al. Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia[J]. INTEGRATIVE ZOOLOGY,2019,14(3):306-317.
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| APA |
Lang, DT,Lim, BK,Gao, Y,&Wang, XP.(2019).Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia.INTEGRATIVE ZOOLOGY,14(3),306-317.
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| MLA |
Lang, DT,et al."Adaptive evolutionary expansion of the ribonuclease 6 in Rodentia".INTEGRATIVE ZOOLOGY 14.3(2019):306-317.
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