Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales

	Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales
	Liu, Zhen; Qi, Fei-Yan; Xu, Dong-Ming; Zhou, Xin; Shi, Peng
	2018
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	4 期号:10
摘要	Echolocation allows toothed whales to adapt to underwater habitats where vision is ineffective. Because echolocation requires the ability to detect exceptional high-frequency sounds, fossils related to the auditory system can help to pinpoint the origin of echolocation in whales. However, because of conflicting interpretations of archaeocete fossils, when and how whales evolved the high-frequency hearing correlated with echolocation remain unclear. We address these questions at the molecular level by systematically investigating the convergent evolution of 7206 orthologs across 16 mammals and find that convergent genes between the last common ancestor of all whales (LCAW) and echolocating bats are not significantly enriched in functional categories related to hearing, and that convergence in hearing-related proteins between them is not stronger than that between nonecholocating mammalian lineages and echolocating bats. However, these results contrast with those of parallel analyses between the LCA of toothed whales (LCATW) and echolocating bats. Furthermore, we reconstruct the ancestral genes for the hearing protein prestin for the LCAW and LCATW; we show that the LCAW prestin exhibits the same function as that of nonecholocating mammals, but the LCATW prestin shows functional convergence with that of extant echolocating mammals. Mutagenesis shows that functional convergence of prestin is driven by convergent changes in the prestins S392A and L497M in the LCATW and echolocating bats. Our results provide genomic and functional evidence supporting the origin of high-frequency hearing in the LCAW, not the LCATW, and reveal molecular insights into the origin and evolutionary trajectories of echolocation in whales.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13112
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Liu, Zhen,Qi, Fei-Yan,Xu, Dong-Ming,et al. Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales[J]. SCIENCE ADVANCES,2018,4(10).
APA	Liu, Zhen,Qi, Fei-Yan,Xu, Dong-Ming,Zhou, Xin,&Shi, Peng.(2018).Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales.SCIENCE ADVANCES,4(10).
MLA	Liu, Zhen,et al."Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales".SCIENCE ADVANCES 4.10(2018).

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