A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution

	A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution
	Yang, Hui; Yang, Songlin; Fan, Fei; Li, Yun; Dai, Shaoxing; Zhou, Xin; Steiner, Cynthia C.; Coppedge, Bretton; Roos, Christian; Cai, Xianghai; Irwin, David M.; Shi, Peng
	2021
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	38 期号:12 页码:5472-5479
摘要	Bitter taste receptors serve as a vital component in the defense system against toxin intake by animals, and the family of genes encoding these receptors has been demonstrated, usually by family size variance, to correlate with dietary preference. However, few systematic studies of specific Tas2R to unveil their functional evolution have been conducted. Here, we surveyed Tas2R16 across all major clades of primates and reported a rare case of a convergent change to increase sensitivity to beta-glucopyranosides in human and a New World monkey, the white-faced saki. Combining analyses at multiple levels, we demonstrate that a parallel amino acid substitution (K172N) shared by these two species is responsible for this functional convergence of Tas2R16. Considering the specialized feeding preference of the white-faced saki, the K172N change likely played an important adaptive role in its early evolution to avoid potentially toxic cyanogenic glycosides, as suggested for the human TAS2R16 gene.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13116
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Yang, Hui,Yang, Songlin,Fan, Fei,et al. A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2021,38(12):5472-5479.
APA	Yang, Hui.,Yang, Songlin.,Fan, Fei.,Li, Yun.,Dai, Shaoxing.,...&Shi, Peng.(2021).A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution.MOLECULAR BIOLOGY AND EVOLUTION,38(12),5472-5479.
MLA	Yang, Hui,et al."A New World Monkey Resembles Human in Bitter Taste Receptor Evolution and Function via a Single Parallel Amino Acid Substitution".MOLECULAR BIOLOGY AND EVOLUTION 38.12(2021):5472-5479.

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