Cochlear hair cells of echolocating bats are immune to intense noise

	Cochlear hair cells of echolocating bats are immune to intense noise
	Liu, Zhen; Chen, Peng; Li, Yuan-Yuan; Li, Meng-Wen; Liu, Qi; Pan, Wen-Lu; Xu, Dong-Ming; Bai, Jing; Zhang, Li-Biao; Tang, Jie; Shi, Peng
	2021
发表期刊	JOURNAL OF GENETICS AND GENOMICS
ISSN	1673-8527
卷号	48 期号:11 页码:984-993
摘要	Exposure to intense noise can damage cochlear hair cells, leading to hearing loss in mammals. To avoid this constraint, most mammals have evolved in relatively quiet environments. Echolocating bats, however, are naturally exposed to continuous intense sounds from their own and neighboring sonar emissions for maintaining sonar directionality and range. Here, we propose the presence of intense noise resistance in cochlear hair cells of echolocating bats against noise-induced hearing loss (NIHL). To test this hypothesis, we performed noise exposure experiments for laboratory mice, one nonecholocating bat species, and five echolocating bat species. Contrary to nonecholocating fruit bats and mice, the hearing and the cochlear hair cells of echolocating bats remained unimpaired after continuous intense noise exposure. The comparative analyses of cochleae transcriptomic data showed that several genes protecting cochlear hair cells from intense sounds were overexpressed in echolocating bats. Particularly, the experimental examinations revealed that ISL1 overexpression significantly improved the survival of cochlear hair cells. Our findings support the existence of protective effects in cochlear hair cells of echolocating bats against intense noises, which provides new insight into understanding the relationship between cochlear hair cells and intense noises, and preventing or ameliorating NIHL in mammals. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13118
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Liu, Zhen,Chen, Peng,Li, Yuan-Yuan,et al. Cochlear hair cells of echolocating bats are immune to intense noise[J]. JOURNAL OF GENETICS AND GENOMICS,2021,48(11):984-993.
APA	Liu, Zhen.,Chen, Peng.,Li, Yuan-Yuan.,Li, Meng-Wen.,Liu, Qi.,...&Shi, Peng.(2021).Cochlear hair cells of echolocating bats are immune to intense noise.JOURNAL OF GENETICS AND GENOMICS,48(11),984-993.
MLA	Liu, Zhen,et al."Cochlear hair cells of echolocating bats are immune to intense noise".JOURNAL OF GENETICS AND GENOMICS 48.11(2021):984-993.

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