A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)

	A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)
	An, Zhifang; Wei, Linna; Xu, Bo; Wang, Zhijie; Gao, Conghui; Li, Jimei; Wei, Lian; Qi, Delin; Shi, Peng; Zhang, Tongzuo; Wei, Dengbang
	2022
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	41 期号:1
摘要	The plateau pika (Ochotona curzoniae) is native to the Qinghai-Tibet Plateau. In this study, the gene that en-codes a heme-binding protein in the pulmonary surfactant (PS) of the pika is identified. The protein is a ho-motetrameric hemoglobin (84) encoded by HBD (d). HBD is expressed in alveolar epithelial type II (ATII) and type I (ATI) cells, upregulated by hypoxia. 84 is secreted into alveolar cavities through osmiophilic multilamel-lar bodies. HBD expression is downregulated by RNAi, which significantly increases hypoxia-inducible factor 1a expression in lung tissue and red blood cells and hemoglobin and blood lactate concentrations but signif-icantly decreases arterial partial pressure of oxygen (PaO2). Our results indicate that plateau pikas physiolog-ically show hypoxemia when HBD expression is downregulated. Therefore, specific HBD expression in the lungs helps plateau pikas to obtain oxygen under hypoxia by maintaining higher PaO2. These findings provide insights into the adaptive mechanisms of plateau pikas to withstand high-altitude environments.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13122
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	An, Zhifang,Wei, Linna,Xu, Bo,et al. A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)[J]. CELL REPORTS,2022,41(1).
APA	An, Zhifang.,Wei, Linna.,Xu, Bo.,Wang, Zhijie.,Gao, Conghui.,...&Wei, Dengbang.(2022).A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae).CELL REPORTS,41(1).
MLA	An, Zhifang,et al."A homotetrameric hemoglobin expressed in alveolar epithelial cells increases blood oxygenation in high-altitude plateau pika (Ochotona curzoniae)".CELL REPORTS 41.1(2022).

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