Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss

	Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss
	Chen, Peng; Hao, Jun-Jun; Li, Meng-Wen; Bai, Jing; Guo, Yuan-Ting; Liu, Zhen; Shi, Peng
	2022
发表期刊	FRONTIERS IN CELLULAR NEUROSCIENCE
卷号	16
摘要	Sensorineural hearing loss (SNHL) is referred to as the most common type of hearing loss and typically occurs when the inner ear or the auditory nerve is damaged. Aging, noise exposure, and ototoxic drugs represent three main causes of SNHL, leading to substantial similarities in pathophysiological characteristics of cochlear degeneration. Although the common molecular mechanisms are widely assumed to underlie these similarities, its validity lacks systematic examination. To address this question, we generated three SNHL mouse models from aging, noise exposure, and cisplatin ototoxicity, respectively. Through constructing gene co-expression networks for the cochlear transcriptome data across different hearing-damaged stages, the three models are found to significantly correlate with each other in multiple gene co-expression modules that implicate distinct biological functions, including apoptosis, immune, inflammation, and ion transport. Bioinformatics analyses reveal several potential hub regulators, such as IL1B and CCL2, both of which are verified to contribute to apoptosis accompanied by the increase of (ROS) in in vitro model system. Our findings disentangle the shared molecular circuits across different types of SNHL, providing potential targets for the broad effective therapeutic agents in SNHL.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13125
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Chen, Peng,Hao, Jun-Jun,Li, Meng-Wen,et al. Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss[J]. FRONTIERS IN CELLULAR NEUROSCIENCE,2022,16.
APA	Chen, Peng.,Hao, Jun-Jun.,Li, Meng-Wen.,Bai, Jing.,Guo, Yuan-Ting.,...&Shi, Peng.(2022).Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss.FRONTIERS IN CELLULAR NEUROSCIENCE,16.
MLA	Chen, Peng,et al."Integrative Functional Transcriptomic Analyses Implicate Shared Molecular Circuits in Sensorineural Hearing Loss".FRONTIERS IN CELLULAR NEUROSCIENCE 16(2022).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023020718.pdf（3561KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文