Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats

	Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats
	Liu, Zhen; Chen, Peng; Xu, Dong-Ming; Qi, Fei-Yan; Guo, Yuan-Ting; Liu, Qi; Bai, Jing; Zhou, Xin; Shi, Peng
	2022
发表期刊	ISCIENCE
卷号	25 期号:4
摘要	The laryngeal echolocation is regarded as one of the conspicuous traits that play major roles in flourishing bats. Whether the laryngeal echolocation in bats originated once, however, is still controversial. We here address this question by performing-molecular convergence analyses between ancestral branches of bats and toothed whales. Compared with controls, the molecular convergences were enriched in hearing-related genes for the last common ancestor of bats (LCAB) and extant echolocating bats, but not for the LCA of Old World fruit bats (LCAP). And the convergent hearing gene prestin of the LCAB and the extant echolocating bats functionally converged. More importantly, the high-frequency hearing of the LCAP-prestin knock-in mice decreased with lower cochlear outer hair cell function compared with the LCAB-prestin knock-in mice. Together, our findings provide multiple lines of evidence suggesting a single origin of laryngeal echolocation in the LCAB and the subsequent loss in the LCAP.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13127
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Liu, Zhen,Chen, Peng,Xu, Dong-Ming,et al. Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats[J]. ISCIENCE,2022,25(4).
APA	Liu, Zhen.,Chen, Peng.,Xu, Dong-Ming.,Qi, Fei-Yan.,Guo, Yuan-Ting.,...&Shi, Peng.(2022).Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats.ISCIENCE,25(4).
MLA	Liu, Zhen,et al."Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats".ISCIENCE 25.4(2022).

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