The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals

	The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals
	Hao, Junjun; Hao, Wuling; Liu, Zhen; Shi, Peng
	2022
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	39 期号:3 页码:msac036
摘要	The prenatal-to-postnatal transition is a pivotal process in the life cycle whereby an organism shifts from responding to intrauterine cues to undergoing extrauterine stresses with many physiological adaptations. However, the molecular basis underlying the evolutionarily conserved physiological adaptations remains elusive. Here, we analyze the transcriptomes of seven organs across developmental time points from five mammalian species by constructing computational coexpression networks and report a developmental shift of gene expression at the perinatal stage. The low-to-high and high-to-low expressed genes tightly coalesce in the functional categories and gene regulatory pathways that implicate the physiological adaptions during the prenatal-to-postnatal transition, including lipid metabolism, circadian rhythm, immune response, cell cycle, and cell division. The low-to-high and high-to-low expressed genes around the perinatal stage tend to form the mutually inhibitory toggle switch gene pairs linking the gene regulatory networks in response to the environmental changes. We thus propose the toggle switch model for the developmental shift of gene expression as a mechanic framework to investigate how the physiological adaptations occur during the prenatal-to-postnatal transition.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13130
专题	科研部门_进化与功能基因组学（施鹏）遗传资源与进化国家重点实验室
推荐引用方式 GB/T 7714	Hao, Junjun,Hao, Wuling,Liu, Zhen,et al. The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals[J]. MOLECULAR BIOLOGY AND EVOLUTION,2022,39(3):msac036.
APA	Hao, Junjun,Hao, Wuling,Liu, Zhen,&Shi, Peng.(2022).The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals.MOLECULAR BIOLOGY AND EVOLUTION,39(3),msac036.
MLA	Hao, Junjun,et al."The Toggle Switch Model for Gene Expression Change during the Prenatal-to-Postnatal Transition in Mammals".MOLECULAR BIOLOGY AND EVOLUTION 39.3(2022):msac036.

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