The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks

	The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks
	Peng, MS; Li, JB; Cai, ZF; Liu, H; Tang, XL; Ying, RC; Zhang, JN; Tao, JJ; Yin, TT; Zhang, T; Hu, JY; Wu, RN; Zhou, ZY; Zhang, ZG; Yu, L; Yao, YG; Shi, ZL; Lu, XM; Lu, J; Zhang, YP
	2021
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	42 期号:6 页码:834-844
摘要	Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks. A significant gap remains for the possible role of pangolins as a reservoir of SARS-CoV-2 related coronaviruses (SC2r-CoVs). Here, we screened SC2r-CoVs in 172 samples from 163 pangolin individuals of four species, and detected positive signals in muscles of four Manis javanica and, for the first time, one M. pentadactyla. Phylogeographic analysis of pangolin mitochondrial DNA traced their origins from Southeast Asia. Using in-solution hybridization capture sequencing, we assembled a partial pangolin SC2r-CoV (pangolin-CoV) genome sequence of 22 895 bp (MP20) from the M. pentadactyla sample. Phylogenetic analyses revealed MP20 was very closely related to pangolin-CoVs that were identified in M. javanica seized by Guangxi Customs. A genetic contribution of bat coronavirus to pangolin-CoVs via recombination was indicated. Our analysis revealed that the genetic diversity of pangolin-CoVs is substantially higher than previously anticipated. Given the potential infectivity of pangolin-CoVs, the high genetic diversity of pangolin-CoVs alerts the ecological risk of zoonotic evolution and transmission of pathogenic SC2r-CoVs.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13140
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Peng, MS,Li, JB,Cai, ZF,et al. The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks[J]. ZOOLOGICAL RESEARCH,2021,42(6):834-844.
APA	Peng, MS.,Li, JB.,Cai, ZF.,Liu, H.,Tang, XL.,...&Zhang, YP.(2021).The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks.ZOOLOGICAL RESEARCH,42(6),834-844.
MLA	Peng, MS,et al."The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks".ZOOLOGICAL RESEARCH 42.6(2021):834-844.

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