The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain

	The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain
	Ruan, YS; Hou, M; Tang, XL; He, XL; Lu, XM; Lu, J; Wu, CI; Wen, HJ
	2022
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	39 期号:3
摘要	In new epidemics after the host shift, the pathogens may experience accelerated evolution driven by novel selective pressures. When the accelerated evolution enters a positive feedback loop with the expanding epidemics, the pathogen's runaway evolution may be triggered. To test this possibility in coronavirus disease 2019 (COVID-19), we analyze the extensive databases and identify five major waves of strains, one replacing the previous one in 2020-2021. The mutations differ entirely between waves and the number of mutations continues to increase, from 3-4 to 21-31. The latest wave in the fall of 2021 is the Delta strain which accrues 31 new mutations to become highly prevalent. Interestingly, these new mutations in Delta strain emerge in multiple stages with each stage driven by 6-12 coding mutations that form a fitness group. In short, the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the oldest to the youngest wave, and from the earlier to the later stages of the Delta wave, is a process of acceleration with more and more mutations. The global increase in the viral population size (M(t), at time t) and the mutation accumulation (R(t)) may have indeed triggered the runaway evolution in late 2020, leading to the highly evolved Alpha and then Delta strain. To suppress the pandemic, it is crucial to break the positive feedback loop between M(t) and R(t), neither of which has yet to be effectively dampened by late 2021. New waves after Delta, hence, should not be surprising.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13150
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Ruan, YS,Hou, M,Tang, XL,et al. The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain[J]. MOLECULAR BIOLOGY AND EVOLUTION,2022,39(3).
APA	Ruan, YS.,Hou, M.,Tang, XL.,He, XL.,Lu, XM.,...&Wen, HJ.(2022).The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain.MOLECULAR BIOLOGY AND EVOLUTION,39(3).
MLA	Ruan, YS,et al."The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain".MOLECULAR BIOLOGY AND EVOLUTION 39.3(2022).

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