Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross

	Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross
	Liu, SJ; Luo, J; Chai, J; Ren, L; Zhou, Y; Huang, F; Liu, XC; Chen, YB; Zhang, C; Tao, M; Lu, B; Zhou, W; Lin, GL; Mai, C; Yuan, S; Wang, J; Li, T; Qin, QB; Feng, H; Luo, KK; Xiao, J; Zhong, H; Zhao, RR; Duan, W; Song, ZY; Wang, YQ; Wang, J; Zhong, L; Wang, L; Ding, ZL; Du, ZL; Lu, XM; Gao, Y; Murphy, RW; Liu, Y; Meyer, A; Zhang, YP
	2016
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	113 期号:5 页码:1327-1332
摘要	Polyploidy is much rarer in animals than in plants but it is not known why. The outcome of combining two genomes in vertebrates remains unpredictable, especially because polyploidization seldom shows positive effects and more often results in lethal consequences because viable gametes fail to form during meiosis. Fortunately, the goldfish (maternal) x common carp (paternal) hybrids have reproduced successfully up to generation 22, and this hybrid lineage permits an investigation into the genomics of hybridization and tetraploidization. The first two generations of these hybrids are diploids, and subsequent generations are tetraploids. Liver transcriptomes from four generations and their progenitors reveal chimeric genes (> 9%) and mutations of orthologous genes. Characterizations of 18 randomly chosen genes from genomic DNA and cDNA confirm the chimera. Some of the chimeric and differentially expressed genes relate to mutagenesis, repair, and cancer-related pathways in 2nF(1). Erroneous DNA excision between homologous parental genes may drive the high percentage of chimeric genes, or even more potential mechanisms may result in this phenomenon. Meanwhile, diploid offspring show paternal-biased expression, yet tetraploids show maternal-biased expression. These discoveries reveal that fast and unstable changes are mainly deleterious at the level of transcriptomes although some offspring still survive their genomic abnormalities. In addition, the synthetic effect of genome shock might have resulted in greatly reduced viability of 2nF(2) hybrid offspring. The goldfish x common carp hybrids constitute an ideal system for unveiling the consequences of intergenomic interactions in hybrid vertebrate genomes and their fertility.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13152
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Liu, SJ,Luo, J,Chai, J,et al. Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2016,113(5):1327-1332.
APA	Liu, SJ.,Luo, J.,Chai, J.,Ren, L.,Zhou, Y.,...&Zhang, YP.(2016).Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,113(5),1327-1332.
MLA	Liu, SJ,et al."Genomic incompatibilities in the diploid and tetraploid offspring of the goldfish x common carp cross".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 113.5(2016):1327-1332.

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