Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals

	Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals
	Yali Hou; ,Furong Qi; ,Xue Bai; ,Tong Ren,Xu Shen,Qin Chu,Xiquan Zhang,and Xuemei Lu*
	2020
发表期刊	BMC Genomics
ISSN	1471-2164
卷号	21 期号:1
摘要	Background In response to ecological niche of domestication, domesticated mammals and birds developed adaptively phenotypic homoplasy in behavior modifications like fearlessness, altered sociability, exploration and cognition, which partly or indirectly result in consequences for economic productivity. Such independent adaptations provide an excellent model to investigate molecular mechanisms and patterns of evolutionary convergence driven by artificial selection. Results First performing population genomic and brain transcriptional comparisons in 68 wild and domesticated chickens, we revealed evolutionary trajectories, genetic architectures and physiologic bases of adaptively behavioral alterations. To extensively decipher molecular convergence on behavioral changes thanks to domestication, we investigated selection signatures in hundreds of genomes and brain transcriptomes across chicken and 6 other domesticated mammals. Although no shared substitution was detected, a common enrichment of the adaptive mutations in regulatory sequences was observed, presenting significance to drive adaptations. Strong convergent pattern emerged at levels of gene, gene family, pathway and network. Genes implicated in neurotransmission, semaphorin, tectonic protein and modules regulating neuroplasticity were central focus of selection, supporting molecular repeatability of homoplastic behavior reshapes. Genes at nodal positions in trans-regulatory networks were preferably targeted. Consistent down-regulation of majority brain genes may be correlated with reduced brain size during domestication. Up-regulation of splicesome genes in chicken rather mammals highlights splicing as an efficient way to evolve since avian-specific genomic contraction of introns and intergenics. Genetic burden of domestication elicits a general hallmark. The commonly selected genes were relatively evolutionary conserved and associated with analogous neuropsychiatric disorders in human, revealing trade-off between adaption to life with human at the cost of neural changes affecting fitness in wild. Conclusions After a comprehensive investigation on genomic diversity and evolutionary trajectories in chickens, we revealed basis, pattern and evolutionary significance of molecular convergence in domesticated bird and mammals, highlighted the genetic basis of a compromise on utmost adaptation to the lives with human at the cost of high risk of neurophysiological changes affecting animals' fitness in wild.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13162
专题	科研部门_适应性进化与进化医学（吕雪梅）昆明动物研究所
推荐引用方式 GB/T 7714	Yali Hou,*,Furong Qi,,Xue Bai,et al. Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals[J]. BMC Genomics,2020,21(1).
APA	Yali Hou,,Furong Qi,,Xue Bai,&,Tong Ren,Xu Shen,Qin Chu,Xiquan Zhang,and Xuemei Lu*.(2020).Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals.BMC Genomics,21(1).
MLA	Yali Hou,et al."Genome-wide analysis reveals molecular convergence underlying domestication in 7 bird and mammals".BMC Genomics 21.1(2020).

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