Venom resistance mechanisms in centipede show tissue specificity

	Venom resistance mechanisms in centipede show tissue specificity
	Wang, YF; Yin, CL; Zhang, H; Kamau, PM; Dong, WQ; Luo, AN; Chai, LH; Yang, SL; Lai, R
	2022
发表期刊	CURRENT BIOLOGY
ISSN	0960-9822
卷号	32 期号:16 页码:3556-+
摘要	Venomous animals utilize venom glands to secrete and store powerful toxins for intraspecific and/or interspecific antagonistic interactions, implying that tissue-specific resistance is essential for venom glands to anatomically separate toxins from other tissues. Here, we show the mechanism of tissue-specific resistance in centipedes (Scolopendra subspinipes mutilans), where the splice variant of the receptor repels its own toxin. Unlike the well-known resistance mechanism by mutation in a given exon, we found that the KCNQ1 channel is highly expressed in the venom gland as a unique splice variant in which the pore domain and transmembrane domain six, partially encoded by exon 6 (rather than 7 as found in other tissues), contain eleven mutated residues. Such a splice variant is sufficient to gain resistance to SsTx (a lethal toxin for giant prey capture) in the venom gland due to a partially buried binding site. Therefore, the tissue-specific KCNQ1 modification confers resistance to the toxins, establishing a safe zone in the venom-storing/secreting environment.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13215
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Wang, YF,Yin, CL,Zhang, H,et al. Venom resistance mechanisms in centipede show tissue specificity[J]. CURRENT BIOLOGY,2022,32(16):3556-+.
APA	Wang, YF.,Yin, CL.,Zhang, H.,Kamau, PM.,Dong, WQ.,...&Lai, R.(2022).Venom resistance mechanisms in centipede show tissue specificity.CURRENT BIOLOGY,32(16),3556-+.
MLA	Wang, YF,et al."Venom resistance mechanisms in centipede show tissue specificity".CURRENT BIOLOGY 32.16(2022):3556-+.

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