| Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis |
| Xu, KH; Zhou, M; Wu, FL; Tang, XP; Lu, QM; Lai, R; Long, CB
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| 2021
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| 发表期刊 | CHINESE JOURNAL OF NATURAL MEDICINES
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| ISSN | 2095-6975
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| 卷号 | 19期号:7页码:540-544 |
| 摘要 | A large number of protease inhibitors have been found from leeches, which are essential in various physiological and biological processes. In the curret study, a novel elastase inhibitor was purified and characterized from the leech of Hirudinaria manillensis, which was named HMEI-A. Primary structure analysis showed that HMEI-A belonged to a new family of proteins. HMEI-A exerted inhibitory effects on elastase and showed potent abilities to inhibit elastase with an inhibition constant (K-i) of 1.69 x 10(-8) mol.L-1. Further study showed that HMEI-A inhibited the formation of neutrophil extracellular trap (NET). These results suggested that HMEI-A from the leech of H. manillensis is a novel elastase inhibitor which can suppress NET formation. It may play a significant role in blood-sucking of leeches and is a potential candidate as an anti-inflammatory agent. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13222
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Xu, KH,Zhou, M,Wu, FL,et al. Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2021,19(7):540-544.
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| APA |
Xu, KH.,Zhou, M.,Wu, FL.,Tang, XP.,Lu, QM.,...&Long, CB.(2021).Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis.CHINESE JOURNAL OF NATURAL MEDICINES,19(7),540-544.
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| MLA |
Xu, KH,et al."Identification and characterization of a novel elastase inhibitor from Hirudinaria manillensis".CHINESE JOURNAL OF NATURAL MEDICINES 19.7(2021):540-544.
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