LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis

	LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis
	Li, PP; Zhang, ZZ; Liao, Q; Meng, E; Mwangi, J; Lai, R; Rong, MQ
	2020
发表期刊	FRONTIERS IN PHARMACOLOGY
ISSN	1663-9812
卷号	11
摘要	Spider venoms contain many functional proteins/peptides such as proteinases, serine/cysteine proteinase inhibitors, insecticidal toxins, and ion channel toxins. However, to date, no peptide toxin with procoagulant activities has been identified from spider venom. In this study, a novel toxin LCTX-F2 with coagulation-promoting activity was identified and characterized in the venom of the spiderLycosa singoriensis(L. singoriensis). LCTX-F2 significantly shortened activated partial thromboplastin time (APTT), clotting time, and plasma recalcification time. This toxin directly interacted with several coagulation factors such as FXIIa, kallikrein, thrombin, and FXa and increased their protease activities. In liver bleeding and tail bleeding mouse models, LCTX-F2 significantly decreased the number of blood cells and bleeding time in a dose-dependent manner. At the same dosage, LCTX-F2 exhibited a more significant procoagulant effect than epsilon aminocaproic acid (EACA). Moreover, LCTX-F2 showed no cytotoxic or hemolytic activity against either normal cells or red blood cells. Our results suggested that LCTX-F2 is a potentiator of coagulation factors with the potential for use in the development of procoagulant drugs.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13231
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Li, PP,Zhang, ZZ,Liao, Q,et al. LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis[J]. FRONTIERS IN PHARMACOLOGY,2020,11.
APA	Li, PP.,Zhang, ZZ.,Liao, Q.,Meng, E.,Mwangi, J.,...&Rong, MQ.(2020).LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis.FRONTIERS IN PHARMACOLOGY,11.
MLA	Li, PP,et al."LCTX-F2, a Novel Potentiator of Coagulation Factors From the Spider Venom ofLycosa singoriensis".FRONTIERS IN PHARMACOLOGY 11(2020).

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