The Emerging Role of the SLCO1B3 Protein in Cancer Resistance

	The Emerging Role of the SLCO1B3 Protein in Cancer Resistance
	Sun, RP; Ying, Y; Tang, ZM; Liu, T; Shi, FL; Li, HX; Guo, TC; Huang, SB; Lai, R
	2020
发表期刊	PROTEIN AND PEPTIDE LETTERS
ISSN	0929-8665
卷号	27 期号:1 页码:17-29
摘要	Currently, chemotherapy is one of the mainstays of oncologic therapies. But the efficacy of chemotherapy is often limited by drug resistance and severe side effects. Consequently, it is becoming increasingly important to investigate the underlying mechanism and overcome the problem of anticancer chemotherapy resistance. The solute carrier organic anion transporter family member 1B3 (SLCO1B3), a functional transporter normally expressed in the liver, transports a variety of endogenous and exogenous compounds, including hormones and their conjugates as well as some anticancer drugs. The extrahepatic expression of SLCO1B3 has been detected in different cancer cell lines and cancer tissues. Recently, accumulating data indicates that the abnormal expression and function of SLCO1B3 are involved in resistance to anticancer drugs, such as taxanes, camptothecin and its analogs, SN-38, and Androgen Deprivation Therapy (ADT) in breast, prostate, lung, hepatic, and colorectal cancer, respectively. Thus, more investigations have been implemented to identify the potential SLCO1B3-related mechanisms of cancer drug resistance. In this review, we focus on the emerging roles of SLCO1B3 protein in the development of cancer chemotherapy resistance and briefly discuss the mechanisms of resistance. Elucidating the function of SLCO1B3 in chemoresistance may bring out novel therapeutic strategies for cancer treatment.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13240
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Sun, RP,Ying, Y,Tang, ZM,et al. The Emerging Role of the SLCO1B3 Protein in Cancer Resistance[J]. PROTEIN AND PEPTIDE LETTERS,2020,27(1):17-29.
APA	Sun, RP.,Ying, Y.,Tang, ZM.,Liu, T.,Shi, FL.,...&Lai, R.(2020).The Emerging Role of the SLCO1B3 Protein in Cancer Resistance.PROTEIN AND PEPTIDE LETTERS,27(1),17-29.
MLA	Sun, RP,et al."The Emerging Role of the SLCO1B3 Protein in Cancer Resistance".PROTEIN AND PEPTIDE LETTERS 27.1(2020):17-29.

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