Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies

	Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies
	Nie, XK; Chen, QZ; Wang, C; Huang, WX; Lai, R; Lu, QM; He, QY; Yu, XD
	2022
发表期刊	TOXINS
卷号	14 期号:9
摘要	The venom and transcriptome profile of the captive Chinese cobra (Naja atra) is not characterized until now. Here, LC-MS/MS and illumine technology were used to unveil the venom and trascriptome of neonates and adults N. atra specimens. In captive Chinese cobra, 98 co-existing transcripts for venom-related proteins was contained. A total of 127 proteins belong to 21 protein families were found in the profile of venom. The main components of snake venom were three finger toxins (3-FTx), snake venom metalloproteinase (SVMP), cysteine-rich secretory protein (CRISP), cobra venom factor (CVF), and phosphodiesterase (PDE). During the ontogenesis of captive Chinese cobra, the rearrangement of snake venom composition occurred and with obscure gender difference. CVF, 3-FTx, PDE, phospholipase A(2) (PLA(2)) in adults were more abundant than neonates, while SVMP and CRISP in the neonates was richer than the adults. Ontogenetic changes in the proteome of Chinese cobra venom reveals different strategies for handling prey. The levels of different types of toxin families were dramatically altered in the wild and captive specimens. Therefore, we speculate that the captive process could reshape the snake venom composition vigorously. The clear comprehension of the composition of Chinese cobra venom facilitates the understanding of the mechanism of snakebite intoxication and guides the preparation and administration of traditional antivenom and next-generation drugs for snakebite.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13249
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Nie, XK,Chen, QZ,Wang, C,et al. Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies[J]. TOXINS,2022,14(9).
APA	Nie, XK.,Chen, QZ.,Wang, C.,Huang, WX.,Lai, R.,...&Yu, XD.(2022).Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies.TOXINS,14(9).
MLA	Nie, XK,et al."Venom Variation of Neonate and Adult Chinese Cobras in Captivity concerning Their Foraging Strategies".TOXINS 14.9(2022).

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