Gene editing in monogenic autism spectrum disorder: animal models and gene therapies

	Gene editing in monogenic autism spectrum disorder: animal models and gene therapies
	Wang, N; Lv, LB; Huang, XY; Shi, MQ; Dai, YW; Wei, YY; Xu, BA; Fu, CY; Huang, HY; Shi, HL; Liu, Y; Hu, XT; Qin, DD
	2022
发表期刊	FRONTIERS IN MOLECULAR NEUROSCIENCE
ISSN	1662-5099
卷号	15
摘要	Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disease, and its diagnosis is dependent on behavioral manifestation, such as impaired reciprocal social interactions, stereotyped repetitive behaviors, as well as restricted interests. However, ASD etiology has eluded researchers to date. In the past decades, based on strong genetic evidence including mutations in a single gene, gene editing technology has become an essential tool for exploring the pathogenetic mechanisms of ASD via constructing genetically modified animal models which validates the casual relationship between genetic risk factors and the development of ASD, thus contributing to developing ideal candidates for gene therapies. The present review discusses the progress in gene editing techniques and genetic research, animal models established by gene editing, as well as gene therapies in ASD. Future research should focus on improving the validity of animal models, and reliable DNA diagnostics and accurate prediction of the functional effects of the mutation will likely be equally crucial for the safe application of gene therapies.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13273
专题	科研部门_神经系统编码（胡新天）
推荐引用方式 GB/T 7714	Wang, N,Lv, LB,Huang, XY,et al. Gene editing in monogenic autism spectrum disorder: animal models and gene therapies[J]. FRONTIERS IN MOLECULAR NEUROSCIENCE,2022,15.
APA	Wang, N.,Lv, LB.,Huang, XY.,Shi, MQ.,Dai, YW.,...&Qin, DD.(2022).Gene editing in monogenic autism spectrum disorder: animal models and gene therapies.FRONTIERS IN MOLECULAR NEUROSCIENCE,15.
MLA	Wang, N,et al."Gene editing in monogenic autism spectrum disorder: animal models and gene therapies".FRONTIERS IN MOLECULAR NEUROSCIENCE 15(2022).

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