Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression

	Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression
	Liu, K; Pu, J; Nie, Z; Shi, YL; Jiang, LP; Wu, QS; Chen, YB; Yang, CP
	2021
发表期刊	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN	2296-634X
卷号	9
摘要	Glioblastoma (GBM) is the most common and malignant primary brain tumor. Glioblastoma stem cells (GSCs) not only initiate and sustain uncontrolled cell proliferation but also resistant to conventional clinical therapies including temozolomide (TMZ) dependent chemotherapy and radiotherapy, implying that there is an urgent need to identify new therapeutic strategies especially specific targeting GSCs. Here, we provide evidence showing that ivacaftor commonly applied in cystic fibrosis therapy acts as a potent inhibitor for GSCs maintenance. We found that ivacaftor promotes cellular apoptosis in vitro and represses patient-derived xenograft (PDX) tumor growth in vivo. In addition, we demonstrate that ivacaftor decreases stemness marker gene expressions of GSCs, including CD133, CD44, and Sox2. In summary, our findings reveal that ivacaftor inhibits glioblastoma progression via specifically eliminating GSCs, which opens a new avenue for GBM clinical therapy in the future.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13278
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Liu, K,Pu, J,Nie, Z,et al. Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2021,9.
APA	Liu, K.,Pu, J.,Nie, Z.,Shi, YL.,Jiang, LP.,...&Yang, CP.(2021).Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9.
MLA	Liu, K,et al."Ivacaftor Inhibits Glioblastoma Stem Cell Maintenance and Tumor Progression".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023032902.pdf（4786KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文