The role of m6A modification in the biological functions and diseases

	The role of m6A modification in the biological functions and diseases
	Jiang, XL; Liu, BY; Nie, Z; Duan, LC; Xiong, QX; Jin, ZX; Yang, CP; Chen, YB
	2021
发表期刊	SIGNAL TRANSDUCTION AND TARGETED THERAPY
ISSN	2095-9907
卷号	6 期号:1
摘要	N-6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the demethylases, or erasers, including FTO and ALKBH5. It is recognized by m6A-binding proteins YTHDF1/2/3, YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1, also known as readers. Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of different types of human cancers. In this review, we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems. We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation, its regulators and downstream target genes, during cancer progression in above systems. We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13281
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Jiang, XL,Liu, BY,Nie, Z,et al. The role of m6A modification in the biological functions and diseases[J]. SIGNAL TRANSDUCTION AND TARGETED THERAPY,2021,6(1).
APA	Jiang, XL.,Liu, BY.,Nie, Z.,Duan, LC.,Xiong, QX.,...&Chen, YB.(2021).The role of m6A modification in the biological functions and diseases.SIGNAL TRANSDUCTION AND TARGETED THERAPY,6(1).
MLA	Jiang, XL,et al."The role of m6A modification in the biological functions and diseases".SIGNAL TRANSDUCTION AND TARGETED THERAPY 6.1(2021).

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