Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer

	Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer
	Yuan, YX; Jiang, XL; Tang, L; Wang, J; Duan, LC
	2022
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
卷号	8
摘要	Platelet-activating factor acetylhydrolase 1B3 (PAFAH1B3) plays a critical role in cancer initiation, metastasis, and progression; however, it remains unknown how PAFAH1B3 impacts cancer diagnosis and prognosis or regulates the immune response to different types of cancer. In this study, PAFAH1B3 was elevated in human pan-cancer, and this correlated with greater pathology and poor prognosis, in particular for non-small cell lung cancer (NSCLC) and liver hepatocellular carcinoma (LIHC). In addition, PAFAH1B3 expression was positively associated with tumor mutational burden (TMB), microsatellite instability (MSI), immune cell infiltration, immune-modulatory related gene expression, and diverse cancer drug sensitivity in human cancer. Increased PAFAH1B3 expression correlated with poor overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) of NSCLC and LIHC, and has potential as an independent risk factor for overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) during LIHC. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis confirmed that PAFAH1B3 is primarily involved in immune regulation. More importantly, results demonstrated that PAFAH1B3 was upregulated in liver cancer cells lines and that knockdown of this gene significantly inhibited cell proliferation, migration, and invasion in liver hepatocellular carcinoma (LIHC). In summary, this study elucidates the clinical significance and biological function of PAFAH1B3 during liver hepatocellular carcinoma (LIHC) and may serve as a potential biomarker for the diagnosis and prognosis of various cancer types.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13290
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Yuan, YX,Jiang, XL,Tang, L,et al. Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,8.
APA	Yuan, YX,Jiang, XL,Tang, L,Wang, J,&Duan, LC.(2022).Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer.FRONTIERS IN MOLECULAR BIOSCIENCES,8.
MLA	Yuan, YX,et al."Comprehensive Analysis of the Prognostic and Immunological Role of PAFAH1B in Pan-Cancer".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2022).

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2023040603.pdf（10135KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文