MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression

	MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression
	Tang, L; Yuan, YX; Zhai, HQ; Wang, J; Zhang, DH; Liang, HS; Shi, YL; Duan, LC; Jiang, XL
	2022
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
卷号	8
摘要	A growing number of studies have focused on investigating microRNAs as crucial regulators in the progression of multiple cancer types. Nevertheless, the biological effects and immunological role of miR-125b-5p in non-small cell lung cancer (lung adenocarcinoma, LUAD) have not been determined. The present study aimed to examine the function of miR-125b-5p on cell proliferation and the outcomes of LUAD patients. We utilized diverse public databases in the analysis of the expression, prognosis, diagnostic value, and immune role of miR-125b-5p in non-small cell lung cancer. The growth curve, colony formation, flow cytometry, and Transwell and invasion assays were utilized to determine the function of miR-125b-5p in LUAD progression. In this study, we found that miR-125b-5p was decreased in LUAD and correlated with poor prognosis. Pathway analyses revealed that miR-125b-5p was mainly involved in cell proliferation and immune regulation. Moreover, in vitro experiments indicated that the overexpression of miR-125b-5p significantly inhibited cell proliferation, migration, and invasion and induced cell apoptosis of LUAD. Finally, we discovered that miR-125b-5p correlated with immune cell infiltration. In summary, these results demonstrated that miR-125b-5p serves as a prognostic marker and a therapeutic target for LUAD.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13300
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Tang, L,Yuan, YX,Zhai, HQ,et al. MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,8.
APA	Tang, L.,Yuan, YX.,Zhai, HQ.,Wang, J.,Zhang, DH.,...&Jiang, XL.(2022).MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression.FRONTIERS IN MOLECULAR BIOSCIENCES,8.
MLA	Tang, L,et al."MicroRNA-125b-5p Correlates With Prognosis and Lung Adenocarcinoma Progression".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2022).

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