Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer

	Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer
	Yuan, YX; Jiang, XL; Tang, L; Yang, H; Wang, J; Zhang, DH; Duan, LC
	2022
发表期刊	FRONTIERS IN MOLECULAR BIOSCIENCES
卷号	9
摘要	IQ motif containing GTPase-activating protein 3 (IQGAP3) is a member of the Rho family of guanosine-5 '-triphosphatases (GTPases). IQGAP3 plays a crucial part in the development and progression of several types of cancer. However, the prognostic, upstream-regulatory, and immunological roles of IQGAP3 in human cancer types are not known. We found that IQGAP3 expression was increased in different types of human cancer. The high expression of IQGAP3 was correlated with tumor stage, lymph node metastasis, and a poor prognosis in diverse types of human cancer. The DNA methylation of IQGAP3 was highly and negatively correlated with IQGAP3 expression in diverse cancer types. High DNA methylation in IQGAP3 was correlated with better overall survival in human cancer types. High mRNA expression of IQGAP3 was associated with tumor mutational burden, microsatellite instability, immune cell infiltration, and immune modulators. Analyses of signaling pathway enrichment showed that IQGAP3 was involved in the cell cycle. IQGAP3 expression was associated with sensitivity to a wide array of drugs in cancer cells lines. We revealed that polypyrimidine tract-binding protein 1 (PTBP1) and an IQGAP3-associated lncRNA (IQGAP3AR)/let-7c-5p axis were potential regulations for IQGAP3 expression. We provided the first evidence to show that an IQGAP3AR/let-7c-5p/IQGAP3 axis has indispensable roles in the progression and immune response in different types of human cancer.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13305
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Yuan, YX,Jiang, XL,Tang, L,et al. Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9.
APA	Yuan, YX.,Jiang, XL.,Tang, L.,Yang, H.,Wang, J.,...&Duan, LC.(2022).Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer.FRONTIERS IN MOLECULAR BIOSCIENCES,9.
MLA	Yuan, YX,et al."Comprehensive Analyses of the Immunological and Prognostic Roles of an IQGAP3AR/let-7c-5p/IQGAP3 Axis in Different Types of Human Cancer".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022).

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