Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma

	Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma
	Jiang, XL; Yuan, YX; Tang, L; Wang, J; Zhang, DH; Cho, WC; Duan, LC
	2022
发表期刊	FRONTIERS IN ONCOLOGY
ISSN	2234-943X
卷号	12
摘要	MiRNA-30a-5p is a microRNA found to be decreased in various human cancers, including lung adenocarcinoma (LUAD). However, the molecular mechanisms of miRNA-30a-5p involve in the progression of LUAD remains unclear. In this study, we found that miRNA-30a-5p expression was significantly decreased in LUAD cells lines, LUAD tissues, and peripheral blood serum. Besides, LUAD patients with decreased miRNA-30a-5p expression exhibit worse clinical outcomes compared to the patients with higher miRNA-30a-5p expression, decreased expression of miRNA-30a-5p was associated with advanced clinical outcomes. Receiver operating characteristic (ROC) curve analysis of miRNA-30a-5p showed an area under the curve (AUC) value of 0.902, indicating its prognostic value in LUAD. Moreover, immune infiltration and gene set enrichment analysis (GSEA) enrichment analyze demonstrated that miRNA-30a-5p expression was associated with immune cell infiltrated in LUAD. Finally, we found that miRNA-30a-5p inhibits cell proliferation, migration, and self-renewal abilities of LUAD in vitro. In summary, this is the first report that miRNA-30a-5p correlated with progression and immune infiltration, which shed some lights on potential prognostic and therapeutic biomarker for LUAD.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13307
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Jiang, XL,Yuan, YX,Tang, L,et al. Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma[J]. FRONTIERS IN ONCOLOGY,2022,12.
APA	Jiang, XL.,Yuan, YX.,Tang, L.,Wang, J.,Zhang, DH.,...&Duan, LC.(2022).Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma.FRONTIERS IN ONCOLOGY,12.
MLA	Jiang, XL,et al."Identification and Validation Prognostic Impact of MiRNA-30a-5p in Lung Adenocarcinoma".FRONTIERS IN ONCOLOGY 12(2022).

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