NCAPH is negatively associated with Mcl-1 in non-small cell lung cancer

	NCAPH is negatively associated with Mcl-1 in non-small cell lung cancer
	Xiong, QX; Fan, SQ; Duan, LC; Liu, BY; Jiang, XL; Chen, XB; Xiong, CY; Tao, QY; Wang, J; Zhang, H; Chen, CJ; Duan, Y
	2020
发表期刊	MOLECULAR MEDICINE REPORTS
ISSN	1791-2997
卷号	22 期号:4 页码:2916-2924
摘要	Lung cancer has a high mortality rate worldwide. Non-SMC condensin I complex subunit H (NCAPH) has been identified to be one of the regulatory subunits of the condensin I complex, which is essential for the correct packaging and segregation of chromosomes in eukaryotes. NCAPH is abnormally overexpressed in various types of cancer. A pro-survival member of the Bcl-2 family, myeloid cell leukemia sequence 1 (Mcl-1) is also frequently overexpressed in multiple cancers and is associated with poorer clinical outcomes for patients. The association of NCAPH and Mcl-1 proteins with the clinical and pathological features of non-small cell lung cancer (NSCLC) remains to be elucidated. In the current study, the positive percentage of NCAPH in the non-cancerous lung tissues was revealed to be higher compared with that in NSCLC. However, the positive percentage of Mcl-1 in the non-cancerous lung tissues was lower compared with NSCLC. In addition, NCAPH high-expression patients had a higher overall survival rate compared with patients exhibiting low expression, whereas the Mcl-1 high-expression group had a lower survival rate. Pairwise association in 260 cases of NSCLC revealed that overexpression of the NCAPH protein was negatively associated with Mcl-1 expression and vice versa. The results of multivariate Cox proportional hazard regression analysis also indicated that NCAPH and Mcl-1 demonstrated potential as distinct prognostic factors that may be used in NSCLC. The expression of NCAPH and Mcl-1 may be associated with, and act as distinct molecular marks for the prediction of a poor prognosis in patients with NSCLC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13311
专题	科研部门_肿瘤信号转导（陈勇彬）
推荐引用方式 GB/T 7714	Xiong, QX,Fan, SQ,Duan, LC,et al. NCAPH is negatively associated with Mcl-1 in non-small cell lung cancer[J]. MOLECULAR MEDICINE REPORTS,2020,22(4):2916-2924.
APA	Xiong, QX.,Fan, SQ.,Duan, LC.,Liu, BY.,Jiang, XL.,...&Duan, Y.(2020).NCAPH is negatively associated with Mcl-1 in non-small cell lung cancer.MOLECULAR MEDICINE REPORTS,22(4),2916-2924.
MLA	Xiong, QX,et al."NCAPH is negatively associated with Mcl-1 in non-small cell lung cancer".MOLECULAR MEDICINE REPORTS 22.4(2020):2916-2924.

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