Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease

	Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease
	Zhang, ZY; Zhang, Y; Ting, YW; Huo, JX; Zheng, EY; Zhang, W; Li, JL
	2022
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	41 期号:5
摘要	Neuropsychiatric symptoms in patients with Alzheimer's disease (AD) are presented as early as the mild cogni-tive impairment (MCI) stage. However, it remains unclear whether separate neuronal populations encode distinct aspects of the neuropsychiatric symptoms and drive them differently. Here, we report that pyramidal tract (PT) neurons projecting to the thalamus, but not to the pons or medulla, in the medial prefrontal cortex (mPFC) of the mouse model of AD show increased excitability, which is associated with increased irritability and aggressivity. Decreased Kv6.3 in corticothalamic PT neurons contributes to hyper-excitability, which is tightly associated with aggressive behaviors. Overexpression of Kv6.3 not only prevents abnormal excitability of corticothalamic PT neurons in mPFC, but also rescues aggressive behaviors of 3xTg model mice. Our study provides causal evidence for the contribution of corticothalamic PT neurons to irritability in the 3xTg model of AD and reveals circuit mechanisms used by PT neurons to regulate neuropsychiatric symptoms in AD.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13317
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Zhang, ZY,Zhang, Y,Ting, YW,et al. Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease[J]. CELL REPORTS,2022,41(5).
APA	Zhang, ZY.,Zhang, Y.,Ting, YW.,Huo, JX.,Zheng, EY.,...&Li, JL.(2022).Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease.CELL REPORTS,41(5).
MLA	Zhang, ZY,et al."Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease".CELL REPORTS 41.5(2022).

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