Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon

	Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon
	Sun, Y; Wang, Q; Wang, Y; Ren, WR; Cao, Y; Li, JL; Zhou, X; Fu, W; Yang, J
	2021
发表期刊	PROTEIN & CELL
ISSN	1674-800X
卷号	12 期号:8 页码:621-638
摘要	Axonal degeneration is one of the key features of neurodegenerative disorders. In the canonical view, axonal degeneration destructs neural connections and promotes detrimental disease defects. Here, we assessed the enteric nervous system (ENS) of the mouse, non-human primate, and human by advanced 3D imaging. We observed the profound neurodegeneration of catecholaminergic axons in human colons with ulcerative colitis, and similarly, in mouse colons during acute dextran sulfate sodium-induced colitis. However, we unexpectedly revealed that blockage of such axonal degeneration by the Sarm1 deletion in mice exacerbated the colitis condition. In contrast, pharmacologic ablation or chemogenetic inhibition of catecholaminergic axons suppressed the colon inflammation. We further showed that the catecholaminergic neurotransmitter norepinephrine exerted a pro-inflammatory function by enhancing the expression of IL-17 cytokines. Together, this study demonstrated that Sarm1-mediated neurodegeneration within the ENS mitigated local inflammation of the colon, uncovering a previously-unrecognized beneficial role of axonal degeneration in this disease context.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13318
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Sun, Y,Wang, Q,Wang, Y,et al. Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon[J]. PROTEIN & CELL,2021,12(8):621-638.
APA	Sun, Y.,Wang, Q.,Wang, Y.,Ren, WR.,Cao, Y.,...&Yang, J.(2021).Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon.PROTEIN & CELL,12(8),621-638.
MLA	Sun, Y,et al."Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon".PROTEIN & CELL 12.8(2021):621-638.

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