Metabolic stress drives sympathetic neuropathy within the liver

	Metabolic stress drives sympathetic neuropathy within the liver
	Liu, KL; Yang, L; Wang, G; Liu, JQ; Zhao, X; Wang, Y; Li, JL; Yang, J
	2021
发表期刊	CELL METABOLISM
ISSN	1550-4131
卷号	3 期号:3 页码:666-+
摘要	The nervous system instructs the body's metabolism, including that in the liver. However, the neural anatomy of the liver under either normal or metabolically stressed conditions remains to be unequivocally assessed. Here, we examined neural distributions in the mouse, nonhuman primate, and human livers with advanced 3D imaging. We observed that neural innervations within the liver are predominantly sympathetic, but not para-sympathetic, inputs. Moreover, we discovered the profound and reversible loss of such sympathetic innervations during metabolic challenges. This hepatic sympathetic neuropathy was caused by TNF alpha derived from CD11b(+) F4/80(+) immune cells under high-fat-diet (HFD) condition. We further demonstrated that the Sarm1 deletion mitigated the hepatic sympathetic neuropathy and improved metabolic parameters in HFD-challenged mice. Mechanistically, the sympathetic neurotransmitter norepinephrine attenuated the immune-cell inflammation that would otherwise trigger the insulin insensitivity of hepatocytes. These results together reveal the previously unrecognized neuropathic event in the liver with metabolic relevance.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13319
专题	科研部门_表观遗传与神经退行性疾病（李家立）
推荐引用方式 GB/T 7714	Liu, KL,Yang, L,Wang, G,et al. Metabolic stress drives sympathetic neuropathy within the liver[J]. CELL METABOLISM,2021,3(3):666-+.
APA	Liu, KL.,Yang, L.,Wang, G.,Liu, JQ.,Zhao, X.,...&Yang, J.(2021).Metabolic stress drives sympathetic neuropathy within the liver.CELL METABOLISM,3(3),666-+.
MLA	Liu, KL,et al."Metabolic stress drives sympathetic neuropathy within the liver".CELL METABOLISM 3.3(2021):666-+.

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