Genome wide association study identifies four loci for early onset schizophrenia

	Genome wide association study identifies four loci for early onset schizophrenia
	Guo, SQ; Liu, JW; Li, WQ; Yang, YF; Lv, LX; Xiao, X; Li, M; Guan, FL; Luo, XJ
	2021
发表期刊	TRANSLATIONAL PSYCHIATRY
ISSN	2158-3188
卷号	11 期号:1
摘要	Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have identified multiple risk variants for SCZ, most of the cases included in these GWASs were not stratified according to their first age at onset. To date, the genetic architecture of EOS remains largely unknown. To identify the risk variants and to uncover the genetic basis of EOS, we conducted a two-stage GWAS of EOS in populations of Han Chinese ancestry in this study. We first performed a GWAS using 1,256 EOS cases and 2,661 healthy controls (referred as discovery stage). The genetic variants with a P < 1.0 x 10(-04) in discovery stage were replicated in an independent sample (903 EOS cases and 3,900 controls). We identified four genome-wide significant risk loci for EOS in the combined samples (2,159 EOS cases and 6,561 controls), including 1p36.22 (rs1801133, P-meta = 4.03 x 10(-15)), 1p31.1 (rs1281571, P-meta = 4.14 x 10(-08)), 3p21.31 (rs7626288, P-meta = 1.57 x 10(-09)), and 9q33.3 (rs592927, P-meta = 4.01 x 10(-11)). Polygenic risk scoring (PRS) analysis revealed substantial genetic overlap between EOS and SCZ. These discoveries shed light on the genetic basis of EOS. Further functional characterization of the identified risk variants and genes will help provide potential targets for therapeutics and diagnostics.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13323
专题	科研部门_神经系统疾病（罗雄剑）
推荐引用方式 GB/T 7714	Guo, SQ,Liu, JW,Li, WQ,et al. Genome wide association study identifies four loci for early onset schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2021,11(1).
APA	Guo, SQ.,Liu, JW.,Li, WQ.,Yang, YF.,Lv, LX.,...&Luo, XJ.(2021).Genome wide association study identifies four loci for early onset schizophrenia.TRANSLATIONAL PSYCHIATRY,11(1).
MLA	Guo, SQ,et al."Genome wide association study identifies four loci for early onset schizophrenia".TRANSLATIONAL PSYCHIATRY 11.1(2021).

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023032104.pdf（1712KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文