Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Nominates Potential Causal Genes for Parkinson's Disease

	Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Nominates Potential Causal Genes for Parkinson's Disease
	Dang, XL; Zhang, ZJ; Luo, XJ
	2022
发表期刊	MOVEMENT DISORDERS
ISSN	0885-3185
摘要	Background Large-scale genome-wide association studies (GWASs) have reported multiple risk variants for Parkinson's disease (PD). However, little is known about how these reported risk variants confer risk of PD. Objective To nominate genes whose genetically regulated expression in dopaminergic neurons may have a causal role in PD. Methods We conducted a two-sample Mendelian randomization (MR) study by integrating large-scale genome-wide associations and expression quantitative trait loci (eQTL) data from dopaminergic neurons. Results MR analysis nominated 10 risk genes whose genetically regulated expression in dopaminergic neurons may have a causal role in PD. These MR significant genes include FAM200B, NDUFAF2, NUP42, SH3GL2, STX1B, CCDC189, KAT8, PRSS36, VAMP4, and ZSWIM7. Conclusions We report the first MR study of PD by using dopaminergic neuron-specific eQTL and nominate novel risk genes for PD. Further functional characterization of the nominated risk genes will provide mechanistic insights into PD pathogenesis and potential therapeutic targets. (c) 2022 International Parkinson and Movement Disorder Society.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13340
专题	科研部门_神经系统疾病（罗雄剑）
推荐引用方式 GB/T 7714	Dang, XL,Zhang, ZJ,Luo, XJ. Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Nominates Potential Causal Genes for Parkinson's Disease[J]. MOVEMENT DISORDERS,2022.
APA	Dang, XL,Zhang, ZJ,&Luo, XJ.(2022).Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Nominates Potential Causal Genes for Parkinson's Disease.MOVEMENT DISORDERS.
MLA	Dang, XL,et al."Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Nominates Potential Causal Genes for Parkinson's Disease".MOVEMENT DISORDERS (2022).

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