Integrated diversity and shared species analyses of human viromes

	Integrated diversity and shared species analyses of human viromes
	Qiao, YT; Li, ST; Zhang, JM; Liu, Q; Wang, Q; Chen, HJ; Ma, ZS
	2021
发表期刊	ARCHIVES OF VIROLOGY
ISSN	0304-8608
卷号	166 期号:10 页码:2743-2749
摘要	Diversity analysis has been performed routinely on microbiomes, including human viromes. Shared species analysis has been conducted only rarely, but it can be a powerful supplement to diversity analysis. In the present study, we conducted integrated diversity and shared species analyses of human viromes by reanalyzing three published datasets of human viromes with more than 250 samples from healthy vs. diseased individuals and/or rural vs. urban individuals. We found significant differences in the virome diversity measured in the Hill numbers between the healthy and diseased individuals, with diseased individuals exhibiting higher virome diversity than healthy individuals, and rural individual exhibiting higher virome diversity than urban individuals. We applied both read randomization and sample randomization algorithms to perform shared species analysis. With the more conservative sample randomization algorithm, the observed number of shared species was significantly smaller than the expected shared species in 50% (8 of 16) of the comparisons. These results suggest that integrated diversity and shared species analysis can offer more comprehensive insights in comparing human virome samples than standard diversity analysis alone with potentially powerful applications in differentiating the effects of diseases or other meta-factors.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13371
专题	科研部门_计算生物与医学生态学（马占山）
推荐引用方式 GB/T 7714	Qiao, YT,Li, ST,Zhang, JM,et al. Integrated diversity and shared species analyses of human viromes[J]. ARCHIVES OF VIROLOGY,2021,166(10):2743-2749.
APA	Qiao, YT.,Li, ST.,Zhang, JM.,Liu, Q.,Wang, Q.,...&Ma, ZS.(2021).Integrated diversity and shared species analyses of human viromes.ARCHIVES OF VIROLOGY,166(10),2743-2749.
MLA	Qiao, YT,et al."Integrated diversity and shared species analyses of human viromes".ARCHIVES OF VIROLOGY 166.10(2021):2743-2749.

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