| Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC) |
| Li, W; Sun, Y; Dai, L; Chen, HJ; Yi, B; Niu, JK; Wang, L; Zhang, FR; Luo, J; Wang, KH; Guo, R; Li, LW; Zou, Q; Ma, ZS; Miao, YL
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| 2021
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| 发表期刊 | BMC MICROBIOLOGY
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| ISSN | 1471-2180
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| 卷号 | 21期号:1 |
| 摘要 | Background Ulcerative colitis (UC) is one of the primary types of inflammatory bowel disease (IBD), the occurrence of which has been increasing worldwide. Although IBD is an intensively studied human microbiome-associated disease, research on Chinese populations remains relatively limited, particularly on the mucosal microbiome. The present study aimed to analyze the changes in the mucosal microbiome associated with UC from the perspectives of medical ecology and complex network analysis. Results In total, 56 mucosal microbiome samples were collected from 28 Chinese UC patients and their healthy family partners, followed by amplicon sequencing. Based on sequencing data, we analyzed species diversity, shared species, and inter-species interactions at the whole community, main phyla, and core/periphery species levels. We identified four opportunistic pathogens (i.e., Clostridium tertium, Odoribacter splanchnicus, Ruminococcus gnavus, and Flavonifractor plautii) with potential significance for the diagnosis and treatment of UC, which were inhibited in healthy individuals, but unrestricted in the UC patients. In addition, we also discovered in this study: (i) The positive-to-negative links (P/N) ratio, which measures the balance of species interactions or inhibition effects in microbiome networks, was significantly higher in UC patients, indicating loss of inhibition against potentially opportunistic pathogens associated with dysbiosis. (ii) Previous studies have reported conflicting evidence regarding species diversity and composition between UC patients and healthy controls. Here, significant differences were found at the major phylum and core/periphery scales, but not at the whole community level. Thus, we argue that the paradoxical results found in existing studies are due to the scale effect. Conclusions Our results reveal changes in the ecology and network structure of the gut mucosal microbiome that might be associated with UC, and these changes might provide potential therapeutic mechanisms of UC. The four opportunistic pathogens that were identified in the present study deserve further investigation in future studies. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13378
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| 专题 | 科研部门_计算生物与医学生态学（马占山）
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推荐引用方式
GB/T 7714 |
Li, W,Sun, Y,Dai, L,et al. Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)[J]. BMC MICROBIOLOGY,2021,21(1).
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| APA |
Li, W.,Sun, Y.,Dai, L.,Chen, HJ.,Yi, B.,...&Miao, YL.(2021).Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).BMC MICROBIOLOGY,21(1).
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| MLA |
Li, W,et al."Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC)".BMC MICROBIOLOGY 21.1(2021).
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