| Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution |
| Ma, PC; Liu, XY; Xu, ZX; Liu, HM; Ding, XN; Huang, Z; Shi, CG; Liang, LC; Xu, LH; Li, XL; Li, GM; He, YQ; Ding, ZL; Chai, CC; Wang, HY; Qiu, JY; Zhu, JC; Wang, XL; Ding, PW; Zhou, S; Yuan, YT; Wu, WD; Wan, C; Yan, YN; Zhou, YT; Zhou, QJ ; Wang, GD; Zhang, QJ; Xu, X; Li, G; Zhang, SH; Mao, BY; Chen, DS
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| 2022
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| 发表期刊 | CELL REPORTS
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| ISSN | 2211-1247
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| 卷号 | 39期号:12 |
| 摘要 | Vertebrate evolution was accompanied by two rounds of whole-genome duplication followed by functional divergence in terms of regulatory circuits and gene expression patterns. As a basal and slow-evolving chordate species, amphioxus is an ideal paradigm for exploring the origin and evolution of vertebrates. Single-cell sequencing has been widely used to construct the developmental cell atlas of several representative species of vertebrates (human, mouse, zebrafish, and frog) and tunicates (sea squirts). Here, we perform single -nucleus RNA sequencing (snRNA-seq) and single-cell assay for transposase accessible chromatin sequencing (scATAC-seq) for different stages of amphioxus (covering embryogenesis and adult tissues). With the datasets generated, we constructed a developmental tree for amphioxus cell fate commitment and lineage specification and characterize the underlying key regulators and genetic regulatory networks. The data are publicly available on the online platform AmphioxusAtlas. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13385
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| 专题 | 科研部门_发育生物学（毛炳宇）
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推荐引用方式
GB/T 7714 |
Ma, PC,Liu, XY,Xu, ZX,et al. Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution[J]. CELL REPORTS,2022,39(12).
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| APA |
Ma, PC.,Liu, XY.,Xu, ZX.,Liu, HM.,Ding, XN.,...&Chen, DS.(2022).Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution.CELL REPORTS,39(12).
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| MLA |
Ma, PC,et al."Joint profiling of gene expression and chromatin accessibility during amphioxus development at single-cell resolution".CELL REPORTS 39.12(2022).
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