Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning

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	Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning
	Ma, PC; Song, NN; Li, YX; Zhang, Q; Zhang, L; Zhang, LL; Kong, QH; Ma, L; Yang, XC; Ren, BY; Li, CC; Zhao, XD; Li, Y; Xu, Y; Gao, X; Ding, YQ; Mao, BY
	2019
发表期刊	CELL REPORTS
ISSN	2211-1247
卷号	28 期号:2 页码:541-+
摘要	Sonic Hedgehog (Shh) signaling plays crucial roles in patterning the ventral neural tube, which is transformed into opposing gradients of repressor and activator forms of Glis. Here, we show that the fine-tuning of the shape of the Gli gradients through non-proteolytic ubiquitination-mediated nuclear exportation plays an important role in the control of local neural cell fate. Loss of RNF220, a ventral neural-specific ubiquitin E3 ligase, leads to ventral expansion of the intermediate V0 and dorsal expansion of the ventral V3 neurons, while reducing the V1, V2, and motor neurons between them. We show that RNF220 interacts with all Glis, either in their activator or repressor forms; induces their K63-linked ubiquitination; and promotes their nuclear export, likely by unmasking a nuclear export signal in the zinc finger domain. We propose that RNF220 works to refine the Gli gradients during neural patterning by limiting the effective Gli levels in the nucleus.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13388
专题	科研部门_发育生物学（毛炳宇）昆明动物研究所
推荐引用方式 GB/T 7714	Ma, PC,Song, NN,Li, YX,et al. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning[J]. CELL REPORTS,2019,28(2):541-+.
APA	Ma, PC.,Song, NN.,Li, YX.,Zhang, Q.,Zhang, L.,...&Mao, BY.(2019).Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning.CELL REPORTS,28(2),541-+.
MLA	Ma, PC,et al."Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning".CELL REPORTS 28.2(2019):541-+.

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2023030810.pdf（5547KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文