Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1

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	Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1
	Zhang, Q; Zhang, L; Huang, Y; Ma, PC; Mao, BY; Ding, YQ; Song, NN
	2021
发表期刊	CELL DEATH & DISEASE
ISSN	2041-4889
卷号	12 期号:10
摘要	Dopaminergic (DA) neurons in the arcuate nucleus (ARC) of the hypothalamus play essential roles in the secretion of prolactin and the regulation of energy homeostasis. However, the gene regulatory network responsible for the development of the DA neurons remains poorly understood. Here we report that the transcription factor special AT-rich binding protein 2 (Satb2) is required for the development of ARC DA neurons. Satb2 is expressed in a large proportion of DA neurons without colocalization with proopiomelanocortin (POMC), orexigenic agouti-related peptide (AgRP), neuropeptide-Y (NPY), somatostatin (Sst), growth hormone-releasing hormone (GHRH), or galanin in the ARC. Nestin-Cre;Satb2(flox/flox) (Satb2 CKO) mice show a reduced number of ARC DA neurons with unchanged numbers of the other types of ARC neurons, and exhibit an increase of serum prolactin level and an elevated metabolic rate. The reduction of ARC DA neurons in the CKO mice is observed at an embryonic stage and Dlx1 is identified as a potential downstream gene of Satb2 in regulating the development of ARC DA neurons. Together, our study demonstrates that Satb2 plays a critical role in the gene regulatory network directing the development of DA neurons in ARC.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13390
专题	科研部门_发育生物学（毛炳宇）
推荐引用方式 GB/T 7714	Zhang, Q,Zhang, L,Huang, Y,et al. Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1[J]. CELL DEATH & DISEASE,2021,12(10).
APA	Zhang, Q.,Zhang, L.,Huang, Y.,Ma, PC.,Mao, BY.,...&Song, NN.(2021).Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1.CELL DEATH & DISEASE,12(10).
MLA	Zhang, Q,et al."Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1".CELL DEATH & DISEASE 12.10(2021).

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