Canalized gene expression during development mediates caste differentiation in ants

	Canalized gene expression during development mediates caste differentiation in ants
	Qiu, BT; Dai, XQ; Li, PY; Larsen, RS; Li, RY; Price, AL; Ding, G; Texada, MJ; Zhang, XF; Zuo, DS; Gao, QH; Jiang, W; Wen, TG; Pontieri, L; Guo, CX; Rewitz, K; Li, QY; Liu, WW; Boomsma, JJ; Zhang, GJ
	2022
发表期刊	NATURE ECOLOGY & EVOLUTION
ISSN	2397-334X
卷号	6 期号:11 页码:1753-+
摘要	Ant colonies are higher-level organisms consisting of specialized reproductive and non-reproductive individuals that differentiate early in development, similar to germ-soma segregation in bilateral Metazoa. Analogous to diverging cell lines, developmental differentiation of individual ants has often been considered in epigenetic terms but the sets of genes that determine caste phenotypes throughout larval and pupal development remain unknown. Here, we reconstruct the individual developmental trajectories of two ant species, Monomorium pharaonis and Acromyrmex echinatior, after obtaining >1,400 whole-genome transcriptomes. Using a new backward prediction algorithm, we show that caste phenotypes can be accurately predicted by genome-wide transcriptome profiling. We find that caste differentiation is increasingly canalized from early development onwards, particularly in germline individuals (gynes/queens) and that the juvenile hormone signalling pathway plays a key role in this process by regulating body mass divergence between castes. We quantified gene-specific canalization levels and found that canalized genes with gyne/queen-biased expression were enriched for ovary and wing functions while canalized genes with worker-biased expression were enriched in brain and behavioural functions. Suppression in gyne larvae of Freja, a highly canalized gyne-biased ovary gene, disturbed pupal development by inducing non-adaptive intermediate phenotypes between gynes and workers. Our results are consistent with natural selection actively maintaining canalized caste phenotypes while securing robustness in the life cycle ontogeny of ant colonies. Using individual transcriptomes of two ant species, the authors show that caste differentiation is canalized from early development and identify key regulatory genes for the development of ant caste phenotypes.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13428
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Qiu, BT,Dai, XQ,Li, PY,et al. Canalized gene expression during development mediates caste differentiation in ants[J]. NATURE ECOLOGY & EVOLUTION,2022,6(11):1753-+.
APA	Qiu, BT.,Dai, XQ.,Li, PY.,Larsen, RS.,Li, RY.,...&Zhang, GJ.(2022).Canalized gene expression during development mediates caste differentiation in ants.NATURE ECOLOGY & EVOLUTION,6(11),1753-+.
MLA	Qiu, BT,et al."Canalized gene expression during development mediates caste differentiation in ants".NATURE ECOLOGY & EVOLUTION 6.11(2022):1753-+.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023031515.pdf（16566KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文