The germline mutational process in rhesus macaque and its implications for phylogenetic dating

	The germline mutational process in rhesus macaque and its implications for phylogenetic dating
	Bergeron, LA; Besenbacher, S; Bakker, J; Zheng, J; Li, PY; Pacheco, G; Sinding, MHS; Kamilari, M; Gilbert, MTP; Schierup, MH; Zhang, GJ
	2021
发表期刊	GIGASCIENCE
ISSN	2047-217X
卷号	10 期号:5
摘要	Background: Understanding the rate and pattern of germline mutations is of fundamental importance for understanding evolutionary processes. Results: Here we analyzed 19 parent-offspring trios of rhesus macaques (Macaca mulatto) at high sequencing coverage of similar to 76x per individual and estimated a mean rate of 0.77 x 10(-8 )de novo mutations per site per generation (95% CI: 0.69 x 10(-8) to 0.85 x 10(-8)). By phasing 50% of the mutations to parental origins, we found that the mutation rate is positively correlated with the paternal age. The paternal lineage contributed a mean of 81% of the de novo mutations, with a trend of an increasing male contribution for older fathers. Approximately 3.5% of de novo mutations were shared between siblings, with no parental bias, suggesting that they arose from early development (postzygotic) stages. Finally, the divergence times between closely related primates calculated on the basis of the yearly mutation rate of rhesus macaque generally reconcile with divergence estimated with molecular clock methods, except for the Cercopithecoidea/Hominoidea molecular divergence dated at 58 Mya using our new estimate of the yearly mutation rate. Conclusions: When compared to the traditional molecular clock methods, new estimated rates from pedigree samples can provide insights into the evolution of well-studied groups such as primates.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13440
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Bergeron, LA,Besenbacher, S,Bakker, J,et al. The germline mutational process in rhesus macaque and its implications for phylogenetic dating[J]. GIGASCIENCE,2021,10(5).
APA	Bergeron, LA.,Besenbacher, S.,Bakker, J.,Zheng, J.,Li, PY.,...&Zhang, GJ.(2021).The germline mutational process in rhesus macaque and its implications for phylogenetic dating.GIGASCIENCE,10(5).
MLA	Bergeron, LA,et al."The germline mutational process in rhesus macaque and its implications for phylogenetic dating".GIGASCIENCE 10.5(2021).

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